Acetamide, N-[2-(5-hydroxy-2-methyl-1H-indol-3-yl)ethyl]-2-methoxy-
SPR inhibitor 3
CAS: 1292285-54-1
Molecular Formula: C14H18N2O3
Acetamide, N-[2-(5-hydroxy-2-methyl-1H-indol-3-yl)ethyl]-2-methoxy- - Names and Identifiers
| Name | SPR inhibitor 3 |
| Synonyms | SPRi 3 SPR inhibitor 3 N-[2-(5-Hydroxy-2-methyl-1H-indol-3-yl)ethyl]-2-methoxyacetamide Acetamide, N-[2-(5-hydroxy-2-methyl-1H-indol-3-yl)ethyl]-2-methoxy- |
| CAS | 1292285-54-1 |
Acetamide, N-[2-(5-hydroxy-2-methyl-1H-indol-3-yl)ethyl]-2-methoxy- - Physico-chemical Properties
| Molecular Formula | C14H18N2O3 |
| Molar Mass | 262.3 |
| Density | 1.241±0.06 g/cm3(Predicted) |
| Boling Point | 561.9±50.0 °C(Predicted) |
| pKa | 10.14±0.40(Predicted) |
| Storage Condition | -20°C，密封，干燥 |
| In vitro study | SPR inhibitor 3 (SPRi3) also significantly reduces SPR activity in mouse primary cultures of sensory neurons (IC 50 =0.45 μM) without affecting the activity of GTP cyclohydroxylase 1 enzyme (GCH1). |
Acetamide, N-[2-(5-hydroxy-2-methyl-1H-indol-3-yl)ethyl]-2-methoxy- - Reference Information
| biological activity | SPR inhibitor 3 (SPRi3) is a potent inhibitor of sepahead reductase (SPR). SPR inhibitor 3 (SPRi3) showed high binding affinity (IC50=74 nM) to human SPR in acellular systems, effective reduction of biopterin levels in the cellular assay (IC50=5.2 μM). SPR inhibitor 3 (SPRi3) reduces neuropathic and inflammatory pain by reducing BH4 levels. |
| Target | IC50: 74 nM |
Last Update：2024-04-09 20:52:54
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